Angel's first movie role was in the 1985 American comedy, Spies Like Us, in which she played a soldier in the Soviet Strategic Missile Forces. In 1990, she appeared in a small role in the movie King of New York. Angel continued to appear in films throughout the early 1990s.

In 1994, she starred in the television series Weird Science. The show ran for five seasons, ending in 1998. In 1995, Angel was cast in the role of Xena, originally intended to be a three-episode guest spot on Hercules: The Legendary Journeys. Due to an illness, she was unable to take the role. Ultimately, the role went to Lucy Lawless.

During the series run of Weird Science, Angel landed the female lead in the Farrelly brothers film, Kingpin. After completing the last season of Weird Science, she played roles in Kissing a Fool with David Schwimmer, followed by a role in the 1999 film, Made Men. In 2004, she appeared in Superbabies: Baby Geniuses 2, as Scott Baio's wife.Angel has also had roles in Sabretooth and The Perfect Score.

In 2000, she guest starred in three episodes of Stargate SG-1. Angel played the role of Tok'ra archaeologist/scientist Freya, whose symbiote is named Anise. Her first appearance is in the Season 4 episode "Upgrades", and she appeared in the two following episodes, "Crossroads" and "Divide and Conquer".

In 2005, Angel played herself in the Season 2 episode of Entourage entitled "I Love You Too". In 2007, she completed the independent film Blind Ambition.